REGIS Technologies is proud to be a leader in chiral separations and serve both the analytical and preparative needs of chromatographers and researchers worldwide. Regis offers three different classes of Chiral Stationary Phases (CSPs):

• Pirkle-Concept

• Davankov Ligand Exchange

• Protein-based

 

■ Pirkle Stationary Phases

 

Regis manufactures nine Pirkle CSPs. These CSPs offer many advantages:

• Enantiomer separation on a wide variety of compound groups

• Column durability resulting from covalent phase bonding

• Ability to invert elution order

• Excellent chromatographic efficiency

• Availability of analytical- to preparative-sized columns and bulk packing material

• Accurate determination of enantiomeric excess, especially in trace analyses

• Universal solvent compatibility

 

These can separate a wide variety of enantiomers in numerous compound groups. Examples include:

• Aryl Propionic Acid Non-Steroidal Anti-inflammatory Drugs (NSAIDs)

• Agricultural Compounds

• Natural Products

• Β-Blockers

• Many Pharmaceuticals

 

　

The differences between Regis Pirkle-Type Chiral Stationary Phases

Phase

Particle Size

Pore Size

Silica Pattern

Application

Whelk-O 1

5μm,

10μm

100Å

Spherical,

Irregular

It can separate underivatized enantiomers in a number of families including amides, epoxides, esters ureas, carbamates, ethers, aziridines, phosphonates, aldehydes, ketones, carboxylic acids, alcohols and NSAIDs.

Whelk-O 2

10μm

100Å

Spherical

In most cases the enantioselectivity remains the same as that obtained with the Whelk-O 1. Whelk-O 2 was designed to improve the resistance of the stationary phase to hydrolysis while using strong organic modifiers such as trifluoroacetic acid.

Leucine 

(D-, L-)

　

5μm

5μm

100Å

100Å

Aminopropyl Silica

This phase demonstrates enhanced enantioselectivities for several classes of compounds, including benzodiazapines.

Phenylglycine 

(D-, L-)

5μm

100Å

Aminopropyl Silica

This CSP resolves a wide variety of compounds containing Π-basic groups.

　

100Å

β-Gem 1

5μm

100Å

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It can separate anilide derivatives of chiral carboxylic acids, including nonsteroidal anti-flammatory agents.

α-Burke 2

5μm

100Å

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This chiral stationary phase is particularly valuable in the HPLC separation of β-blocker enantiomers without chemical derivatization, an important class of cardiovascular drugs whose enantiomers often exhibit differing pharmacological activities.

Pirkle 1-J

5μm

100Å

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It is useful for the direct separation of underivatized β-blocker enantiomers、arylpropionic acid NSAIDs enantiomers.

L-Naphthylleucine

5μm

100Å

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This phase resolves DNB derivatives of amino acids as the free acid when used in reversed-phase mode. In the classic normal-phased, this CSP can resolve the amides and esters of DNB amines, alcohols and amino acids.
DACH-DNB 5,10μm 100Å

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 This phase resolve a broad range of racemate classes including amines, alcohols, esters, ketones, sulfoxides, phosphine oxides, selenoxides, phosphonates, beta-lactams, thiophospineoxide,phosphineselenide, phosphine-borane, organometallics, atropisomers, acids and heterocycles.
ULMO 5,10μm 100Å

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 It can separate the enantiomers of many racemate classes and is particulary good at separating the enantiomers of aryl cabinols.

  

■ Davankov Ligand Exchange

 The Davankov CSP is useful for the separation of underivatized amino acid enantiomers.

 

　

　

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